Core Insights - The article emphasizes the importance of extending healthy life expectancy in the context of an aging population, highlighting the role of gut microbiota in aging and chronic inflammation [1][4]. Company Overview - Guangxi Aisheng Life Technology Co., Ltd. (Aisheng Life) is a national high-tech enterprise focused on longevity research, having established the world's largest longevity human database and microbiome library [1][4]. - The company has published multiple longevity research findings in renowned international journals over its 7+ years of operation, showcasing its influence in the field [1][4]. Recent Research Achievements - Aisheng Life's research team published a paper in the journal Aging Cell, exploring the causal relationships between gut microbes, aging indicators, and age-related diseases, revealing the potential of gut microbiota as biomarkers for health management and disease prevention [4][5]. - The study innovatively integrated gut microbiota, various aging indicators, and numerous age-related diseases into a comprehensive research framework, confirming the significant role of gut microbiota in aging and disease [5][7]. Research Methodology and Findings - The research utilized Mendelian randomization (MR) and linkage disequilibrium score regression (LDSC) to analyze the genetic correlations and causal relationships between gut microbiota and three aging indicators (telomere length, frailty index, and facial aging) as well as 14 age-related diseases (e.g., coronary heart disease, chronic kidney disease, Alzheimer's disease) [5][7]. - Specific gut microbes, such as Bifidobacterium breve, were found to be associated with delayed aging and reduced disease risk, while the enrichment of pathogenic bacteria could increase chronic inflammation and metabolic disorders [5][7]. Predictive Models and Applications - The research team developed predictive models for nine age-related diseases based on identified gut microbes, achieving an average AUC value of 0.832, indicating strong predictive performance [7][10]. - The findings suggest that gut microbiota can causally influence aging indicators by regulating short-chain fatty acid (SCFA) production, improving gut barrier function, and reducing chronic inflammation [7][8]. Future Directions - The study lays a theoretical foundation for developing targeted interventions against aging by modulating gut microbiota, providing new directions for health management, disease early screening, and personalized interventions [8][9]. - Aisheng Life aims to align its development philosophy with national strategies, promoting the application of longevity research outcomes and expanding the global longevity market [8][9]. Innovations and Patents - Aisheng Life has received national invention patent authorization for a probiotic strain (Lactobacillus A21013 and A21033) that has demonstrated efficacy in extending lifespan, reducing fat, enhancing exercise capacity, and improving stress resistance [12]. - The company has also patented another strain (Lactobacillus A21041) with anti-inflammatory and antioxidant properties, which has shown potential in extending lifespan and reducing fat, indicating high practical value for developing longevity products [13][16].
衰老、疾病与菌群存在因果关联?爱生生命顶刊发文揭示长寿奥秘
Sou Hu Wang·2025-05-12 07:48