新研究揭示提升癌症免疫疗法有效性的关键因素

Group 1 - The core finding of the research is the identification of unique genetic characteristics of T cell clones that may predict the efficacy of cancer immunotherapy, paving the way for personalized treatment approaches [1][2] - Immunotherapy is recognized as a revolutionary breakthrough in cancer treatment, capable of precisely eliminating cancer cells by activating the immune system, but individual patient differences pose significant challenges to its widespread application [1] - The research involved a meta-analysis of single-cell RNA sequencing and T cell receptor sequencing data from numerous cancer patients who underwent immunotherapy, focusing on the relationship between T cell clone characteristics and the success of the therapy [1] Group 2 - The study revealed that while T cell clones exist in both responsive and non-responsive cancer patients, those in responsive patients exhibit a distinct genetic feature and enhanced immune activity due to immunotherapy [2] - It was determined that activating T cell clones present only within tumors, rather than those found in both tumors and blood, is crucial for improving the effectiveness of immunotherapy in treating cancer [2] - This research provides significant insights into the dynamic mechanisms of the human immune system in the cancer fighting process, as published in the latest issue of the journal "Cell Genomics" [2]