我国合成生物企业破解PHA量产难题

Core Insights - Shanghai Blue Crystal Microbial Technology Co., Ltd. has achieved significant breakthroughs in the field of polyhydroxyalkanoates (PHA) biomanufacturing, addressing global plastic pollution and carbon neutrality challenges [1][4] - The company has set a global record with a production yield of 300 grams per liter, a 100% carbon source conversion rate, and a 64% reduction in carbon footprint [1][4] Group 1: PHA Production and Characteristics - PHA is a natural biodegradable polymer synthesized by microorganisms, with a degradation efficiency 100 times that of traditional plastics [2] - The historical challenge of scaling PHA production has been addressed by Blue Crystal's innovative use of oil-based raw materials, reducing production costs to $590 per ton [2][3] - The company has achieved a production concentration of 300 grams per liter, surpassing previous industrial benchmarks [2][4] Group 2: Technological Innovations - The Biohybrid technology system developed by the research team has led to two major innovations, enhancing production efficiency and carbon source utilization [4] - The 1.0 version activated the Calvin cycle in industrial strains, increasing fermentation tank yields by 20% [4] - The 2.0 version optimized the oil utilization capacity of strains, achieving a carbon source conversion rate exceeding 100% [4] Group 3: Environmental Impact - The adoption of Biohybrid 2.0 technology has reduced the carbon footprint of PHA to 2.01 kilograms of CO2 equivalent per kilogram, marking a 64% decrease compared to traditional petrochemical plastics [4] - PHA can degrade in approximately two weeks to six months under natural conditions, significantly faster than conventional plastics [5]