Ascletis Announces First Participants Dosed in a U.S. Clinical Study Combining Adipose-Targeted, Once-Monthly Injectable Small Molecule THRβ Agonist, ASC47, and Semaglutide for the Treatment of Obesity

About ASC47-103 Study - The combination study is designed to evaluate the safety and preliminary efficacy of a single-dose of ultra- long-acting subcutaneously administered ASC47 in combination with four doses of semaglutide (0.5 mg, once- weekly) in participants with obesity. - As an adipose-targeted, muscle-preserving weight loss drug candidate for the treatment of obesity, ASC47 monotherapy demonstrated a half-life of up to 40 days in a Phase Ib study in participants with obesity. - In a head-to-head die ...