Codexis' Landmark Presentations at TIDES USA Highlight Reproducibility and Process Simplification of the ECO Synthesis Platform for Manufacturing siRNA

Core Insights - Codexis presented its proprietary ECO Synthesis platform at the TIDES USA annual meeting, demonstrating its effectiveness in siRNA manufacturing by reducing purification costs and improving process performance [1][2] - The company has established itself as a leader in enzymatic technology for siRNA manufacturing, with increasing customer interest in incorporating this technology into drug development [2][3] - Codexis showcased a machine learning tool that significantly enhances the ligation process for siRNA production, improving efficiency and reducing development time [4][6] Group 1: Technology and Performance - The ECO Synthesis platform utilizes immobilized enzymes to achieve consistent process performance, with potential reductions in downstream purification steps [3][6] - Codexis' ligation processes have been validated by leading CDMOs, confirming the transferability and effectiveness of its technology in various manufacturing settings [5][7] - The company reported a coupling efficiency of over 98% and a 24% reduction in average cycle time, leading to high yields of 30 grams of siRNA per liter [6][7] Group 2: Market Position and Future Outlook - Codexis is positioned to capitalize on the growing trend towards enzymatic manufacturing solutions and onshoring initiatives, making its technology rollout timely [2][3] - The company aims to establish a GMP scale-up partnership by the end of the year, translating current momentum into tangible business growth [2][3] - The ability to control stereochemistry in oligonucleotide synthesis through the ECO Synthesis platform could enhance the therapeutic potency and market position of siRNA products [8]