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上海君实生物医药科技股份有限公司关于部分募投项目子项目变更及金额调整的公告

Core Viewpoint - The company plans to adjust certain sub-projects and funding amounts within its fundraising projects to enhance the efficiency of fund utilization while keeping the total investment amount unchanged for the "Innovative Drug R&D Project" [2][3][4]. Fundraising Basic Information - The company was approved to issue 70 million A-shares at a price of RMB 53.95 per share, raising a total of RMB 3,776.5 million. After deducting issuance costs of RMB 31.7 million, the net amount raised was RMB 3,744.8 million, with actual funds received amounting to RMB 3,759.4 million [4]. Fundraising Project Overview - As of December 31, 2024, the company has outlined the usage of funds raised from the 2022 A-share issuance, focusing on various clinical research projects [5]. Specific Changes and Adjustments - New sub-projects added include JS207, JS107, JS125, JT002, JS203, and JS015, with funding sourced from reductions in other sub-projects [6][8][9][10][11][12]. - The company plans to allocate RMB 76.67 million to JS207 for clinical trials in lung cancer, breast cancer, liver cancer, and colorectal cancer [7]. - JS107 will receive RMB 37.8 million for clinical trials targeting gastric and pancreatic cancers [9]. - JS125 will be allocated RMB 16 million for clinical trials in colorectal cancer [12]. - JT002 will receive RMB 15.95 million for clinical trials in allergic rhinitis [10]. - JS203 will be allocated RMB 11 million for clinical trials in lymphoma [11]. - JS015 will receive RMB 3 million for clinical trials in gastrointestinal tumors [12]. Reasons for Changes - The adjustments are based on the progress of ongoing research and market competition, aiming to optimize resource allocation and focus on projects with higher international potential and competitive advantages [5][6]. Company Capabilities - The company possesses strong drug discovery and development capabilities, with a comprehensive R&D system covering various therapeutic areas, including oncology and autoimmune diseases [28][29]. - The company has established a complete technical system for drug development, including multiple key technology platforms [29][30]. - The management team is experienced, with expertise across the entire drug development lifecycle [30][31]. Impact of Changes - The adjustments are expected to improve the efficiency of fund utilization and accelerate the progress of R&D projects, aligning with the company's long-term development strategy [33][37].