Shareholder Update

Core Viewpoint - Biodexa Pharmaceuticals PLC is providing an update on its financial position and the progress of its eRapa Phase 3 program, which targets Familial Adenomatous Polyposis (FAP) and highlights the significant market opportunity for its innovative treatments [2][3][7]. Financial Position - As of May 29, 2025, the company had cash resources totaling $10.1 million, which includes $5.7 million in cash at bank and $4.4 million in escrow for the eRapa Phase 3 program. Additionally, there is an undrawn CPRIT grant of $11.9 million for the same program, and the company has a debt of $0.5 million. The company projects sufficient working capital to fund operations into the first quarter of 2026 [3]. Issued Shares and Market Capitalization - The total number of ordinary shares outstanding as of May 29, 2025, is 50,506,308,922, equivalent to 5,050,630 American Depositary Shares (ADSs). The market capitalization based on the closing share price of $1.06 per ADS is approximately $5.4 million [4]. eRapa Phase 3 Program - The Phase 3 study of eRapa for FAP is in the final stages of implementation, involving a double-blind placebo-controlled trial with 168 patients, randomized in a 2:1 ratio of drug to placebo. The study will take place across approximately 30 clinical sites in the US and Europe, with recruitment expected to begin shortly [5]. About FAP - Familial Adenomatous Polyposis (FAP) is characterized by the proliferation of polyps in the colon and/or rectum, typically starting in mid-teens. There are currently no approved therapeutic options for FAP patients, making the development of eRapa particularly significant [6]. Market Opportunity - The addressable market for eRapa in FAP is estimated at approximately $7.3 billion, based on the lowest prevalence estimates in the US and Europe, with adult populations of approximately 258 million and 358 million, respectively. The median annual cost of approved non-biologic orphan drugs in the US is $206,176 [7]. About eRapa - eRapa is a proprietary oral tablet formulation of rapamycin (sirolimus), an mTOR inhibitor. It is designed to improve bioavailability and reduce toxicity associated with existing forms of rapamycin. Phase 2 study results indicated eRapa was safe and well-tolerated, showing a median 17% reduction in total polyp burden at 12 months compared to baseline [8].