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Regeneron Expands Clinical-Stage Obesity Portfolio with Strategic In-Licensing of Novel Dual GLP-1/GIP Receptor Agonist
RegeneronRegeneron(US:REGN) Globenewswireยท2025-06-02 11:05

Core Insights - Regeneron Pharmaceuticals has entered into a strategic in-licensing agreement with Hansoh Pharmaceuticals to acquire exclusive rights for HS-20094, a dual GLP-1/GIP receptor agonist currently in Phase 3 testing in China [1][2] - The agreement includes an upfront payment of $80 million and potential additional payments of up to $1.93 billion based on development, regulatory, and sales milestones [2] - The acquisition aims to enhance Regeneron's pipeline focused on obesity treatments, addressing the quality of weight loss and associated long-term health benefits [3][5] Company Strategy - Regeneron is committed to improving obesity treatments by focusing on the quality of weight loss, aiming to sustain weight loss while preserving muscle mass [3][4] - The company plans to study combinations of HS-20094 with its proprietary drugs to address muscle loss and other obesity-related comorbidities such as cardiovascular diseases and diabetes [3][5] - Regeneron has a comprehensive pipeline targeting obesity and its related diseases, leveraging its scientific capabilities and clinical innovations [5][6] Clinical Development - HS-20094 has been studied in over 1,000 patients and is administered as a weekly subcutaneous injection, showing promising efficacy and safety data [1] - Ongoing clinical trials include a Phase 3 trial in obesity in China and a Phase 2b study in diabetes [1][3] - Regeneron is also conducting the Phase 2 COURAGE study, which investigates the addition of trevogrumab to semaglutide, with interim data announced recently [3]