OBI Pharma Enters ADC Collaboration with TegMine Therapeutics utilizing GlycOBI® and TegMiner™ Enabling Technologies

Core Insights - OBI Pharma and TegMine Therapeutics have entered into a Master Services Agreement (MSA) to collaborate on antibody-drug conjugates (ADCs) [1][2] - The partnership aims to leverage OBI's GlycOBI ADC enabling technologies to identify ADC therapeutic candidates for clinical development [2][3] Company Overview - OBI Pharma is a clinical-stage global oncology company based in Taiwan, established in 2002, focusing on developing novel cancer therapies for patients with high unmet medical needs [5] - TegMine Therapeutics, founded in 2017 and based in San Francisco, specializes in developing next-generation antibody-based therapies targeting cancer-associated glycans and glycoproteins [8][9] Technology and Innovation - OBI's GlycOBI technology is a unique glycan-based ADC platform that is compatible with various antibodies, linkers, and payloads, allowing for site-specific homogenous ADCs [4] - The GlycOBI platform utilizes proprietary enzymatic and linker technologies to enhance conjugation efficiency and reduce aggregation propensity, leading to improved antitumor activity and stability [4][6] Strategic Collaboration - The collaboration is expected to combine the strengths of both companies, with OBI's ADC technology complementing TegMine's focus on targeting cancer-specific glycans [3] - Both companies anticipate developing ADCs with unprecedented tumor specificity and therapeutic impact, addressing significant medical needs [3]