新研究发现可能抑制炎症风暴的细胞膜“开关”

Core Insights - A new study led by Chinese scientists published in Nature reveals that cell membranes have an "on-off switch" that actively regulates membrane rupture, potentially opening new avenues for treating diseases related to inflammatory storms, such as sepsis [1][2] Group 1: Research Findings - The study identifies a protein called NINJ1 as the "switch" that controls the susceptibility of cell membranes to rupture [1] - The research team developed a high-throughput cell tension stimulation system to apply various physical stresses to cells, simulating conditions encountered in the body [1] - NINJ1 expression significantly lowers the tension threshold required for membrane rupture, making membranes more prone to break under stress [1] Group 2: Implications for Disease Treatment - Inhibiting NINJ1 can significantly reduce membrane rupture and the release of "danger signals" that trigger strong inflammatory responses [2] - This discovery suggests that NINJ1 plays a critical role in inflammatory responses and could serve as a novel target for regulating stress-related tissue damage and excessive inflammation in diseases like lung injury, brain trauma, and sepsis [2]