类似“抓娃娃机”技术可高效分选胚胎模型

Core Viewpoint - A research team from the University of Washington and the Brotman Baty Institute has developed a "claw machine"-like technology for the rapid and automated classification of embryoid bodies, providing critical support for studying individual differences in early embryonic development and the mechanisms of genetic diseases [1][2]. Group 1: Technology Development - The newly developed automated sorting system integrates microscopy, cameras, and robotic micro-manipulation technology, featuring a detachable micro-structure called "micro-raft" for the growth of embryoid bodies [2]. - The system operates like a high-precision "claw machine," autonomously scanning large arrays of "micro-rafts," identifying the characteristics of embryoid bodies, and physically sorting them based on preset criteria, enhancing precision and efficiency [2]. Group 2: Research Implications - The embryoid body model can reveal early developmental abnormalities similar to human diseases, previously clarifying how Huntington's disease manifests genetic traits in early embryos, even before traditional clinical symptoms appear [2]. - The new platform can sort unique embryoid bodies exhibiting subtle phenotypic differences, maintaining sample integrity and paving the way for subsequent live-cell imaging or genetic sequencing [2].