周杰伦患的强直性脊柱炎，为何被称为“不死的癌症”？

Core Viewpoint - Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial joints, often misdiagnosed as other conditions like lumbar muscle strain. Early intervention is crucial for managing the disease effectively [2][5][6]. Summary by Sections Disease Overview - Ankylosing spondylitis is characterized by inflammation starting at the sacroiliac joints and progressing to the spine, leading to chronic pain and stiffness [2]. - The disease primarily affects the sacroiliac joints, spinal joints, and major joints in the limbs, potentially causing limited mobility and severe deformities if untreated [2][6]. Symptoms and Diagnosis - Patients often experience significant pain at rest, which improves with activity, contrasting with other lumbar conditions where pain worsens with movement [3]. - The average time from symptom onset to correct diagnosis can take seven to eight years, with many patients misdiagnosed due to non-specific symptoms [2]. Demographics and Risk Factors - The prevalence of ankylosing spondylitis in China is approximately 0.3%, with a higher incidence in young males aged 20-30 years [4]. - Genetic factors, particularly the HLA-B27 gene, and environmental factors such as humidity and high altitude may increase the risk of developing AS [4]. Treatment and Management - Although AS cannot be completely cured, effective management through standardized treatment can control disease progression and improve quality of life [6]. - Key management strategies include maintaining good posture, regular exercise, a healthy diet, avoiding smoking, and regular medical check-ups [6][7][8].