通心络对心脑血管具有三重保护作用，关键循证证据与临床获益全解析

Core Viewpoint - The newly released "Guidelines for Percutaneous Coronary Intervention (2025)" recommends Tongxinluo capsules for the treatment of acute coronary syndrome, particularly for patients undergoing interventional therapy, highlighting its benefits in myocardial ischemia, improving no-reflow, and reducing complications [1][7]. Group 1: Triple Protective Effects of Tongxinluo - Tongxinluo has been shown to have a triple protective effect on ischemic cardiovascular and cerebrovascular diseases, supported by extensive research [2][7]. - The three protective effects include blood protection, vascular protection, and microvascular protection of ischemic tissues [4][5][6]. Group 2: Blood Protection - Tongxinluo exhibits lipid-lowering, anti-inflammatory, anticoagulant, and anti-thrombotic effects, making it a valuable addition to standard treatments like statins and aspirin [4]. - It can reduce aspirin resistance and dosage, thereby minimizing bleeding side effects [4]. Group 3: Vascular Protection - Tongxinluo effectively relieves vascular spasms and stabilizes plaques, with an 83% success rate in relieving vascular spasms [5]. - It has been recognized as the only innovative traditional Chinese medicine recommended for relieving vascular spasms in expert consensus [5]. Group 4: Microvascular Protection - After PCI, 5% to 50% of patients may experience no-reflow due to coronary microcirculation dysfunction, particularly in acute myocardial infarction cases [6]. - Tongxinluo activates eNOS to protect endothelial cells and improve microcirculation, reducing no-reflow incidence by 36.6% and enhancing myocardial recovery [6]. Group 5: Clinical Evidence and Recommendations - Tongxinluo has received over 30 national guidelines and consensus recommendations for its clinical application in treating cardiovascular diseases [13][14]. - It is particularly recommended for various stages of ischemic cardiovascular diseases, including acute coronary syndrome and stable angina [14][15]. Group 6: Research and Awards - Tongxinluo has been recognized with multiple national awards for its contributions to the treatment of coronary heart disease and related research [18]. - It has been approved for registration and sale in several countries, including Vietnam, Canada, and Singapore, demonstrating its international recognition [20].