我科学家揭示 阿尔茨海默病早期病理机制

Core Insights - The research conducted by the team led by Yao Yonggang and Zhang Dengfeng from the Kunming Institute of Zoology, Chinese Academy of Sciences, provides new insights into the cellular and molecular pathological changes in the choroid plexus of Alzheimer's disease mice during the early stages of the disease, potentially aiding in the development of early intervention strategies for Alzheimer's disease [1][2] Group 1: Research Findings - The study constructed a single-cell transcriptome map related to the choroid plexus in Alzheimer's disease for the first time, elucidating the cellular and molecular pathological changes in the early stages of the disease [2] - The choroid plexus is composed of various cell types, with epithelial cells accounting for approximately 75% of the total cell population [2] - The permeability of choroid plexus epithelial cells in Alzheimer's disease mice was found to be increased, indicating a compromised barrier function [2] Group 2: Immune Response - The choroid plexus contains multiple myeloid and lymphoid immune cell subpopulations, with some lymphocytes, macrophages, and dendritic cell subpopulations expressing proliferation signals, suggesting a "lymph node-like" proliferation of immune cells in situ [2] - Downregulation of macrophage migration inhibitory factor expression in the choroid plexus epithelial cells of Alzheimer's disease mice leads to disrupted immune cell communication and macrophage activation [2] Group 3: Gender Differences - The study identified significant gender differences in the gene expression profile of the choroid plexus, providing data support for future research on the pathological mechanisms and interventions related to gender differences in Alzheimer's disease [2]