海南大学绘制微米精度的“脑部乐高图谱”

Core Insights - The research led by Professor Luo Qingming from Hainan University and the Huazhong University of Science and Technology has successfully created a three-dimensional brain atlas of mice with a precision of 1 micron, providing a crucial tool for understanding brain science [2][3] - The findings were published in the international academic journal "Nature," marking a significant breakthrough in global brain science research [2][3] Research Methodology - The research team developed a method for Nissl staining and resin fixation of the entire mouse brain, transforming it into a transparent "crystal brain" to capture detailed images of brain cell structures [2] - A total of 14,000 coronal sections, 11,400 sagittal sections, and 9,000 horizontal sections were obtained, resulting in sub-micron resolution images of the entire mouse brain [2] Findings and Applications - The team delineated and labeled a three-dimensional adjustable map of 916 brain regions, including 236 newly discovered subregions, revealing unknown neural connectivity networks [3] - This brain atlas serves as a precise "brain Lego model," significantly enhancing the understanding of normal brain functions and dysfunction mechanisms in various diseases, including Alzheimer's disease, epilepsy, and depression [3]