研究：细颗粒物污染与非吸烟者肺癌基因突变增加有关

Core Findings - An international research team published a study in Nature indicating that fine particulate matter pollution may increase the risk of cancer gene mutations in non-smokers, leading to a higher likelihood of lung cancer compared to the effects of secondhand smoke [1] Group 1: Research Overview - The study was conducted by researchers from the National Institutes of Health and the University of California, San Diego, analyzing tumor samples from 871 non-smoking lung cancer patients across 28 regions globally [1] - The research found a strong correlation between fine particulate matter pollution, including vehicle emissions and industrial discharges, and the increase in cancer-related gene mutations in non-smokers [1] Group 2: Genetic Implications - The study identified mutations in the TP53 gene and various other mutations previously associated with smoking, which were linked to exposure to air pollution [1] - Air pollution was found to cause premature shortening of telomeres, leading to early cellular aging and potentially accelerating tumor progression [1] Group 3: Comparative Analysis - The findings suggest that air pollution has a higher likelihood of inducing gene mutations in non-smokers compared to secondhand smoke [1]