研究说一种趋化因子有望用于优化人造血液生产

Core Insights - An international research team has made significant progress in artificial blood research, discovering a chemokine that triggers the expulsion of the nucleus from erythroblast cells, a crucial step in red blood cell development [1][2] - The study indicates that the chemokine CXCL12, found in bone marrow, can be added to erythroblast cells to artificially induce nuclear expulsion, potentially optimizing the production of artificial red blood cells [2] Group 1: Research Findings - The research highlights that the process of nuclear expulsion occurs only in mammals, allowing more space for hemoglobin, which is responsible for oxygen transport [1] - Current methods for artificial red blood cell production using stem cells have a nuclear expulsion success rate of about 80%, but stem cell sources are limited for large-scale production [1] - An alternative method involves reprogramming other cell types into stem cells for red blood cell production, which offers nearly unlimited cell sources but has a nuclear expulsion success rate of only about 40% [1] Group 2: Implications and Mechanisms - The study provides new insights into the cellular biology mechanisms of red blood cells' response to chemokines, suggesting that chemokine receptors may also act within the cell, not just on the surface [2] - This research opens new perspectives for understanding the role of chemokines and their receptors in cellular biology, which could have broader implications beyond red blood cell production [2]