Amylyx Drug Slashes Sugar Spikes Post-Weight Loss Surgery

Core Insights - Amylyx Pharmaceuticals presented new exploratory analyses of avexitide at the Endocrine Society's annual meeting, focusing on its potential to treat post-bariatric hypoglycemia (PBH) [1] Group 1: Clinical Trials and Efficacy - The Phase 2b trial of avexitide showed a 64% reduction in moderate to severe hypoglycemic events with a 90 mg once-daily dose, and over half of participants experienced no such events during treatment [2] - The ongoing Phase 3 LUCIDITY trial is evaluating avexitide's safety and efficacy in approximately 75 patients with PBH following Roux-en-Y gastric bypass surgery, with a primary endpoint of reducing Level 2 and 3 hypoglycemic events [3] - Previous trials demonstrated consistent, dose-dependent reductions in hypoglycemic events, with the 90 mg dose showing sustained 24-hour GLP-1 receptor inhibition [4] Group 2: Safety Profile and Future Prospects - Across five clinical trials, avexitide has shown statistically and clinically meaningful efficacy with a favorable safety profile [5] - LUCIDITY is expected to complete enrollment in 2025, with top-line results anticipated in the first half of 2026 and a potential commercial launch in 2027 [5] Group 3: Market Impact - Following the presentation of these findings, AMLX stock increased by 7.55%, reaching $8.26 [5]