对话国家生物医学成像科学中心副主任陈良怡：“国之重器”12年攻坚路

Core Insights - The establishment of the multi-modal cross-scale biomedical imaging facility represents a significant advancement in China's biomedical research capabilities, aiming to transform the research paradigm from reductionism to a holistic approach [1][2][3] Group 1: Facility Overview - The multi-modal cross-scale biomedical imaging facility is a major scientific infrastructure project in China, with a total investment of 1.717 billion yuan, located in Beijing Huairou Science City, covering an area of 100 acres, and officially passing national acceptance in March this year [1][2] - This facility is the only one in the world that spans ten time and spatial scales, enabling comprehensive observation and measurement of biological systems from molecular to organ levels [1][3] Group 2: Research and Development Goals - The facility aims to provide advanced observational tools for biomedical research, addressing key challenges in understanding complex diseases and facilitating drug development [3][5] - It is designed to support national-level scientific plans and enhance the efficiency of basic and clinical research, while also fostering the development of new talent in emerging fields [2][3] Group 3: Technological Innovations - Key devices within the facility include multi-modal high-resolution molecular imaging, live cell imaging, ultra-high field magnetic resonance imaging, and a full-scale image integration system [3] - The facility has achieved significant breakthroughs in high temporal and spatial resolution imaging technologies, allowing for real-time observation of biological processes [6][9] Group 4: Addressing Domestic Challenges - The facility aims to overcome the "bottleneck" issues in high-end scientific instrument development in China, promoting the domestic replacement of advanced biomedical imaging technologies [9][12] - The facility's construction has led to the development of several world-leading technologies and instruments, with a goal of achieving 40% original technology, 30% customization, and 30% procurement [9][10] Group 5: Future Aspirations - The facility plans to initiate a national-level major scientific project within five years and aims to become one of the top three biomedical imaging centers globally within ten to fifteen years [14] - It seeks to foster a cross-disciplinary innovation ecosystem, integrating various fields such as imaging theory, probe development, and artificial intelligence to enhance research capabilities [13][14]