默沙东半年报：总营收略降至313亿美元，中国区收入显著承压

Core Insights - Merck's total revenue for the first half of the year was $31.335 billion, a 2% year-over-year decline, with pharmaceutical revenue at $27.688 billion, down 3% [1] - Sales of the core HPV vaccine plummeted, with revenue in China dropping 70% to $1.075 billion, representing only 3.9% of Merck's global pharmaceutical business [1] - Keytruda (pembrolizumab) sales grew by 7% to $15.16 billion, but the growth rate has slowed compared to 18% in the first half of 2024 [1] - Gardasil/Gardasil9 sales were significantly down by 48%, totaling $2.453 billion [1] - In response to declining performance, Merck initiated a cost-saving plan aimed at saving $3 billion annually until the end of 2027, with funds reinvested in new product launches and multiple therapeutic areas [1] Strategic Moves - Merck is implementing a restructuring plan that includes job cuts in administrative, sales, and R&D positions while continuing to hire in strategic growth areas [1] - The company plans to reduce its global real estate footprint and optimize its manufacturing network [1] Market Challenges - Keytruda faces challenges as key patents will expire in 2028, with biosimilars and domestic PD-1 innovations threatening market share [2] - Geopolitical tensions and trade wars pose additional risks, particularly with the U.S. imposing tariffs on many countries, affecting production based in Ireland [2] - Merck has taken measures to transfer sufficient inventory to the U.S. to mitigate tariff impacts by the end of 2025 [2] Future Outlook - For the full year 2025, Merck projects global sales between $64.3 billion and $65.3 billion, amidst multiple pressures [2] - The company is betting on chronic obstructive pulmonary disease (COPD) as a new growth area, announcing a $10 billion acquisition of Verona Pharma, focusing on its recently approved product, Ensifentrine [2] - Ensifentrine is expected to become a breakthrough therapy for COPD, with market sales projected to exceed $1 billion, potentially reaching $4 billion [2]