Mei Ri Jing Ji Xin Wen·2025-08-01 12:04Core Insights - Eli Lilly announced positive results from the SURPASS-CVOT phase 3 study, confirming the clinical value of tirzepatide in cardiovascular and renal protection for type 2 diabetes patients [1] - The study covered over 13,000 adult patients with type 2 diabetes and atherosclerotic cardiovascular disease across 30 countries, making it the largest and longest follow-up study of tirzepatide to date [1] - Tirzepatide demonstrated comparable cardiovascular protection to dulaglutide while showing advantages in glycemic control, weight loss, and renal protection, as well as improvements in all-cause mortality risk [1] Company Developments - Kenneth Custer, Executive Vice President of Eli Lilly, emphasized that SURPASS-CVOT results indicate tirzepatide retains cardiovascular protective effects while providing additional health benefits, reinforcing its potential as a first-line treatment for type 2 diabetes patients with cardiovascular disease [2] - Eli Lilly plans to submit the SURPASS-CVOT data to global regulatory agencies by the end of this year and will present detailed results at the EASD annual meeting in September 2025 [3] Industry Trends - The competition among GLP-1 receptor agonists is intensifying, with a focus on differentiated indications, as seen with Novo Nordisk's semaglutide recently approved for chronic kidney disease [2][3] - Both Eli Lilly and Novo Nordisk are pursuing various indications for their GLP-1 formulations, with tirzepatide in clinical studies for conditions such as psoriasis, non-alcoholic steatohepatitis, chronic kidney disease, and obesity [3] - The GLP-1 market is expected to evolve, expanding from weight loss effects to comprehensive management of related indications, indicating multiple catalysts ahead [3]