新发现基因关联脑进化和语言功能

Group 1 - The research team from the University of California, Davis, has discovered two genes related to human brain characteristics and established a systematic research framework to explore more related genes [1][2] - The study utilized the complete human genome map created by the "Telomere to Telomere" (T2T) consortium, identifying approximately 250 candidate gene families that are actively expressed in the brain, verified across all human individuals, and highly conserved [2] - The specific functions of the two identified genes, GPR89B and FRMPD2B, were confirmed through zebrafish model experiments, with GPR89B regulating brain size and FRMPD2B involved in synaptic signaling [2] Group 2 - The findings fill a gap in the research of genomic repeat sequences and provide critical targets for the precise screening of gene mutations associated with language deficits and autism [2] - The constructed dataset from this research is expected to become an important resource for the scientific community, aiding in the understanding of brain evolution and neurodevelopmental diseases [2] - The role of these genes in the formation of unique human brain characteristics offers key insights for future treatments of related diseases through the in-depth analysis of this "genomic dark matter" [2]