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Quantum BioPharma Announces Very Promising Results from the Massachusetts General Hospital Scientists on the Novel Positron Emission Tomography (PET) Tracer Used to Detect and Monitor Demyelination in Multiple Sclerosis Patients

Company Overview - Quantum BioPharma Ltd. is a biopharmaceutical company focused on developing innovative assets and biotech solutions for neurodegenerative and metabolic disorders, as well as alcohol misuse disorders [4] - The company is advancing its lead compound, Lucid-MS, which is a patented new chemical entity aimed at preventing and reversing myelin degradation, a key mechanism in multiple sclerosis (MS) [4] Research and Development - A joint clinical study with Massachusetts General Hospital (MGH) is evaluating the PET tracer [F]3F4AP, which has shown the ability to detect differences across lesions in MS patients that are not visible through conventional MRI [2][3] - The study, published in the European Journal of Nuclear Medicine and Molecular Imaging, indicates that the PET tracer could serve as a significant biomarker for monitoring demyelination and myelin integrity in MS patients [2][3] Clinical Implications - The ongoing collaborative study aims to further assess the imaging agent's potential to demonstrate the effectiveness of Quantum BioPharma's investigational drug, Lucid-21-302, which is designed to protect the myelin sheath in MS [4] - Dr. Andrzej Chruscinski, Vice-President of Scientific and Clinical Affairs at Quantum BioPharma, emphasized the promising nature of the PET tracer as a biomarker for MS lesions [4] Financial and Strategic Position - Quantum BioPharma retains a 20.10% ownership stake in Unbuzzd Wellness Inc., which is involved in the development of unbuzzd™, with a royalty agreement that includes 7% of sales until total payments reach $250 million, after which the royalty rate drops to 3% [4] - The company maintains a portfolio of strategic investments through its subsidiary, FSD Strategic Investments Inc., which includes loans secured by residential or commercial property [4]