Can Rising Casgevy Sales Aid CRISPR Therapeutics Post Q2 Earnings?

Core Insights - CRISPR Therapeutics' Casgevy, a one-shot gene therapy, received approval in late 2023 and early 2024 for sickle cell disease and transfusion-dependent beta-thalassemia in the US and Europe [1] - The partnership with Vertex Pharmaceuticals involves a 60:40 split of program costs and profits, with Vertex leading global development and commercialization [1] Sales Performance - Casgevy had a slow start in 2024, generating only $10 million in full-year product revenues for Vertex, but sales increased significantly to $30.4 million in Q2 2025, marking a 114.1% sequential increase [2][8] - Vertex estimates Casgevy sales to reach approximately $124.6 million in 2025 [2] Treatment Centers and Patient Engagement - Over 75 authorized treatment centers are active for Casgevy, with 115 patients completing their first cell collection as of June 2025 [3][8] Revenue Growth Potential - Increasing Casgevy sales could provide a stable revenue base for CRISPR Therapeutics, allowing for greater investment in its gene-editing pipeline and enhancing long-term growth prospects in the competitive cell and gene therapy market [4][8] Competitive Landscape - Other companies in the gene-editing space include Beam Therapeutics, which is developing BEAM-101 for sickle cell disease, and Intellia Therapeutics, which is advancing in vivo therapies for hereditary angioedema and transthyretin amyloidosis [5][6] Stock Performance and Valuation - CRISPR Therapeutics' shares have increased by 40.7% year-to-date, contrasting with a 0.7% decline in the industry [7] - The company's shares trade at a price-to-book value (P/B) ratio of 2.80, below the industry average of 3.15, but above its five-year mean of 2.38 [9] Earnings Estimates - Loss per share estimates for CRISPR Therapeutics for 2025 have widened from $5.58 to $6.22, while estimates for 2026 have narrowed from $4.30 to $4.03 [10]