Leap Therapeutics(US:LPTX) Prnewswireยท2025-08-14 11:00Core Insights - Leap Therapeutics, Inc. reported a strategic realignment focusing on corporate development opportunities for its products sirexatamab and FL-501, alongside a reduction in internal expenses and a review of strategic alternatives to maximize shareholder value [2][11]. Financial Performance - The net loss for the second quarter of 2025 was $16.6 million, a decrease from $20.4 million in the same quarter of 2024, primarily due to reduced research and development and general administrative expenses [5][6]. - Research and development expenses were $10.5 million for Q2 2025, down from $17.9 million in Q2 2024, reflecting a decrease of $7.4 million attributed to lower clinical trial costs and other related expenses [6]. - General and administrative expenses decreased to $1.8 million in Q2 2025 from $3.4 million in Q2 2024, mainly due to reductions in payroll and incentive-based compensation [7]. - The company incurred $4.5 million in restructuring charges related to workforce reduction during the second quarter [8]. Clinical Development - Updated clinical data from the DeFianCe study indicated that sirexatamab showed a statistically significant benefit in overall response rate and progression-free survival in colorectal cancer patients with specific characteristics [3]. Strategic Initiatives - The Board of Directors initiated a process to explore strategic alternatives, including potential sales or partnerships for sirexatamab and FL-501, and engaged Raymond James & Associates, Inc. as an exclusive financial advisor [11]. - The company implemented a workforce reduction of approximately 75% to further reduce spending and preserve capital [11]. Cash Position - As of June 30, 2025, cash and cash equivalents totaled $18.1 million, a decrease from $47.2 million at the end of 2024 [15].