Rein Therapeutics to Present Novel IPF Science and Clinical Development Insights at IPF Summit 2025

Company Overview - Rein Therapeutics is a clinical-stage biopharmaceutical company focused on developing first-in-class therapies for orphan pulmonary and fibrosis indications [3] - The lead product candidate, LTI-03, is a synthetic peptide targeting alveolar epithelial cell survival and inhibiting profibrotic signaling, currently in clinical development [3] - The second product candidate, LTI-01, has completed Phase 1b and Phase 2a trials for loculated pleural effusions and has received Orphan Drug Designation in both the U.S. and E.U. [3] Upcoming Events - Chief Scientific Officer Cory Hogaboam will present at the IPF Summit 2025 on August 19-21, 2025, discussing the role of immune cells and inflammation in idiopathic pulmonary fibrosis (IPF) [2] - CEO Brian Windsor will present on August 21, focusing on innovative clinical trial design and lessons learned from the LTI-03 trial [2] Research and Development Focus - The presentations will cover the modulation of lung-resident macrophages and the potential of Caveolin-scaffolding domain (CSD) peptides in targeting multiple drivers of fibrosis [5] - Rein's Phase 2 trial of LTI-03 aims to enroll up to 120 patients, assessing safety, tolerability, and lung function as key outcomes [5] - The company is strategizing around patient recruitment and trial design to ensure relevance in a rapidly evolving treatment landscape [5]