【科技日报】科研人员发现千叶蓍抗神经炎症关键成分

Core Insights - The research conducted by the Xinjiang Institute of Physics and Chemistry of the Chinese Academy of Sciences has identified the sesquiterpene components of the plant Achillea millefolium as having anti-neuroinflammatory activity, providing a solid foundation for developing natural lead compounds for treating neuroinflammatory diseases [1][2]. Group 1: Research Findings - The study published in the journal "Molecular Structure" highlights the medicinal value of Achillea millefolium, traditionally used in various countries for treating gastrointestinal diseases, liver and gallbladder diseases, hypertension, respiratory infections, fever, and rheumatic diseases, as well as promoting wound healing and alleviating skin inflammation [1]. - Researchers isolated 16 sesquiterpenes from the whole plant of Achillea millefolium collected in the Changji region of Xinjiang, with 12 of these being new compounds, successfully determining their planar structures and absolute configurations using high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy [1]. Group 2: Active Compounds - In further studies, five compounds were found to effectively inhibit nitric oxide secretion in a lipopolysaccharide-induced microglial cell model, with one compound showing activity comparable to dexamethasone [2]. - The research concluded that sesquiterpenes, particularly guaiol-type sesquiterpene lactones, are key components responsible for the significant anti-neuroinflammatory activity of Achillea millefolium [2].