人体细胞会通过变形修复伤口

Core Insights - A new study published in "Nature Cell Biology" reveals that human cells can change their shape to close wound gaps, providing insights into cellular self-repair mechanisms and potential applications in wound healing and tissue regeneration [1] Group 1: Cellular Mechanisms - Epithelial cells, which cover internal and external surfaces of the body, play a crucial role in protecting against physical damage, pathogen invasion, and water loss [1] - The endoplasmic reticulum (ER) in epithelial cells alters its shape in response to wound curvature; it forms tubular structures at convex curves and flat sheet-like structures at concave curves [1] Group 2: Cellular Movement - The driving force at the edges of convex curves and the pulling force at concave curves change the shape of the endoplasmic reticulum through different mechanisms [1] - At the edges of convex cracks, cells extend flat membrane structures through "crawling" movements to fill the gap, while at concave edges, cells contract the edges through "tethering" movements, akin to tightening a rope to close the gap [1] Group 3: Role of Endoplasmic Reticulum - The endoplasmic reticulum reorganizes itself based on the curvature of the wound edges, influencing the migration patterns of epithelial cells, highlighting its critical role in cellular behavior [1]