噬菌体或成破除耐药“新解” 上海已初步构建起研究、临床、制剂、监管协同推进的完整链条

Core Insights - Antibiotic resistance has become a significant global clinical challenge, with an estimated 4 million deaths annually related to antibiotic resistance, including 1.3 million direct deaths [1] - Phage therapy is emerging as a potential breakthrough in addressing antibiotic resistance, as discussed at the recent phage therapy conference held at Fudan University [1] Group 1: Phage Therapy Case Study - A 56-year-old male patient with multiple antibiotic-resistant infections post-kidney transplant underwent unsuccessful surgeries and treatments until phage therapy was applied, leading to significant improvement and stabilization of his condition [1] - The phage therapy involved precise matching of lytic phages, which effectively targeted and destroyed the infection sites in the patient [1] Group 2: Phage Characteristics and Applications - Phages are viruses that specifically attack bacteria and are found abundantly in various environments, including wastewater and soil, with over 6,000 types identified in humans [2] - The European Union has approved the clinical application of phage therapy, and China is advancing in both foundational research and clinical applications, with over 300 successful treatments reported in Shanghai [2] - A complete chain of research, clinical application, formulation, and regulation for phage therapy is being established in Shanghai, indicating progress in this field [2]