研究发现一种蛋白与不孕症和癌症有关

Core Findings - A research team from Kyoto University discovered that STAG3-cohesin protein acts as a "DNA organizer" to help spermatogonial stem cells establish unique genetic structures, which is crucial for sperm production [1][2] - The absence of STAG3 in mice leads to infertility, indicating its essential role in spermatogenesis [2] - STAG3 is also highly active in certain immune cells and blood cancers, suggesting that blocking it could slow down cancer cell growth, presenting new treatment possibilities for infertility and specific cancers [1][2] Group 1 - The study published in "Nature Structural & Molecular Biology" highlights the role of STAG3 in forming isolation layers that organize DNA within the cell nucleus [1] - The research indicates that STAG3 is not only present in spermatogonial stem cells but also forms a new STAG3-cohesin complex with RAD21 protein [2] - Blocking STAG3 in human B cells and B-cell lymphomas significantly reduces the growth rate of lymphoma cells, indicating its potential as a target for future cancer research [2]