“跳跃基因”对人脑早期发育有积极作用

Core Insights - The study reveals that non-coding DNA, previously considered "junk," plays a crucial role in gene regulation and brain development, particularly focusing on transposons known as "jumping genes" [1][2] - The research highlights the significance of LINE-1 (L1) transposons in human brain development, suggesting their active role in regulating neural development and potential links to neurodevelopmental disorders [2] Group 1 - The international research team utilized organoids and CRISPR technology to silence L1 sequences, observing significant disruptions in gene expression and brain organoid growth [1] - The findings indicate that L1 transposons are not merely evolutionary remnants but essential components of the gene regulatory network in the brain [2] Group 2 - The study suggests that the activity of L1 transposons may help explain the differences between human brains and those of other primates from an evolutionary perspective [2] - Ongoing research aims to explore the role of transposons in neurodegenerative diseases like Parkinson's, potentially revealing disease mechanisms and informing future treatment strategies [2]