【科技日报】新型邻近标记技术有望精准打击癌细胞

Group 1 - The article discusses a powerful "molecular mapping technique" known as proximity labeling technology, which allows scientists to catalyze and label the surrounding environment at specific locations within cells, enabling precise identification of specific molecules in the microscopic world [1] - Researchers from the Chinese Academy of Sciences have transformed this technology into a therapeutic tool by developing engineered nanoenzymes responsive to deep red light or ultrasound, successfully creating a powerful "treatment weapon" [1] - In mouse experiments, the team artificially created difficult-to-escape targets on tumors, which not only addresses core challenges in immunotherapy but also stimulates a robust systemic anti-tumor effect [1] Group 2 - The study reveals that in cancer immunotherapy, immune cells require strong and abundant "signals" to initiate attacks, and the natural signals on cancer cells are often sparse [2] - By chemically catalyzing reactions to increase the artificial antigen density on tumor cell surfaces by over 100 times, the researchers significantly enhanced immune recognition efficiency and killing power [2] - The engineered nanoenzymes were instructed to create a strong artificial target on cancer cells, which, when combined with a special bispecific T cell engager, effectively triggered T cells to launch a powerful attack on the targeted area [1][2] Group 3 - After the destruction of cancer cells, more tumor-associated antigens are exposed, which are then captured by antigen-presenting cells and relayed to the immune system, enabling it to autonomously recognize and attack similar cancer cells in the future [2] - The research has shown promising results in both mouse models and clinical tumor samples, paving the way for the development of smarter and more efficient next-generation immunotherapies [2] - In mouse trials, the primary tumor volume was reduced by over 80%, and the immune system activation also suppressed untreated distal tumors, demonstrating long-lasting immune memory against secondary tumor challenges [2]