【中国新闻网】有助精准打击癌细胞 中国科学家巧用邻近标记技术

Core Insights - A research team led by Han Shuo from the Chinese Academy of Sciences has developed a novel proximity labeling technology that enhances the precision of targeting cancer cells [1][2] - The technology allows scientists to label the "neighbors" of specific molecules, enabling a better understanding of their interactions in the microenvironment [1] - The team aims to transform this observation tool into a therapeutic weapon by engineering a nanoenzyme that significantly improves the efficacy of cancer immunotherapy [1][2] Summary by Sections - Research Development - The new proximity labeling technology can increase the targeting effectiveness of cancer immunotherapy by tens to hundreds of times [2] - This method creates a strong artificial target on the surface of cancer cells, which enhances the signaling needed for immune cells to initiate an attack [2] - Experimental Findings - In studies involving mouse tumor models and patient samples from breast, gastric, and colorectal cancers, the engineered nanoenzyme demonstrated significant therapeutic effects [1] - The high-density labeling acts as a rallying signal for immune cells, triggering a "strongest attack mode" for precise targeting [2] - Limitations and Future Directions - There are limitations to the method, such as difficulties in targeting certain melanoma cells with red light alone [2] - Overall, this research is expected to pave the way for the development of smarter and more efficient next-generation immunotherapies [3]