研究：基因或能重塑肠道菌群，成为抵御慢病的新利器

Core Insights - The research from the Charles Perkins Centre at the University of Sydney suggests that gut microbiome health may be influenced by genetics, not just diet, highlighting the role of a natural protein peptide called α-defensin in managing gut bacteria and protecting against unhealthy diets [1][2][3] Group 1: Research Findings - The study indicates that certain genes in mice lead to the production of α-defensin, which helps promote beneficial bacteria while eliminating harmful ones, resulting in healthier gut microbiomes and reduced risk of insulin resistance [1][2] - Mice that produced more α-defensin were found to be healthier compared to those that produced less, and synthetic α-defensin peptides were shown to protect mice from the negative effects of unhealthy diets [2] - The research emphasizes that while gut microbiomes influence various diseases, the body actively shapes its microbiome through genetic factors, suggesting potential for peptide-based treatments for chronic diseases like diabetes and obesity [2][3] Group 2: Implications for Personalized Medicine - The study highlights the importance of personalized medicine, indicating that individuals with different genetic backgrounds may respond differently to treatments involving defensin peptides [2][3] - The research team is expanding their studies to explore the application of α-defensin in human health, particularly its relationship with metabolic health and gut microbiomes [3] - The potential for precision medicine is underscored, as understanding individual responses to treatments could lead to more effective interventions for managing gut microbiomes and associated chronic diseases [3]