小型成像系统可实时观测小鼠大脑活动

Core Insights - A research team from the University of California, Davis has developed a small imaging system called "DeepInMiniscope" that allows for high-resolution, non-invasive real-time observation of brain activity in mice [1][2] - The system is expected to open new pathways for neuroscience research and facilitate the development of new therapies for brain diseases [1] Group 1: Technology and Innovation - The DeepInMiniscope utilizes a novel mask design that integrates over 100 micro high-resolution lenses, employing neural networks to combine images from these lenses to reconstruct high-quality 3D images [1] - The neural network incorporates various machine learning methods to quickly and accurately restore fine structures in a larger 3D space [2] Group 2: Size and Usability - The new microscope measures only 3 square centimeters, approximately the size of a grape, and weighs about 10 grams, making it significantly smaller than previous devices [2] - Its ergonomic design allows for comfortable and safe use by mice during free movement, enhancing usability in behavioral studies [2] Group 3: Future Goals - The ultimate goal of the research is to develop a wireless device that is only 2 square centimeters in size, aimed at deepening the understanding of brain information processing and behavior mechanisms, as well as advancing the recognition and treatment strategies for brain diseases [2]