Comparative Analysis of Pharmaceutical Companies' Capital Utilization

Financial Performance Comparison - Karyopharm Therapeutics Inc. has a Return on Invested Capital (ROIC) of -1634.05% and a Weighted Average Cost of Capital (WACC) of 16.41%, indicating extremely poor capital utilization [1][5] - MacroGenics, Inc. has a ROIC of -37.98% and a WACC of 9.15%, resulting in a ROIC to WACC ratio of -4.15, which is less inefficient compared to Karyopharm [2][5] - TG Therapeutics, Inc. shows a positive ROIC of 15.75% against a WACC of 12.34%, yielding a ROIC to WACC ratio of 1.28, indicating effective capital management [2][5] Industry Context - Heron Therapeutics, Inc. has a ROIC of 0.82% and a WACC of 6.57%, resulting in a ROIC to WACC ratio of 0.12, which is still better than Karyopharm's performance [3] - Intra-Cellular Therapies, Inc. has a ROIC of -10.08% and a WACC of 5.90%, leading to a ROIC to WACC ratio of -1.71, indicating inefficiencies but still better than Karyopharm [3] - Agios Pharmaceuticals, Inc. reports a ROIC of -30.47% and a WACC of 7.57%, resulting in a ROIC to WACC ratio of -4.02, showing inefficiencies but not as severe as Karyopharm's [4]