CRSP & Sirius Begin Dosing in Thromboembolic Disorder Study in EU

Core Insights - CRISPR Therapeutics (CRSP) and Sirius Therapeutics have initiated a phase II study for SRSD107, a long-acting siRNA therapy targeting thromboembolic disorders [1][7] - The study focuses on the prevention of venous thromboembolism (VTE) in patients undergoing total knee arthroplasty (TKA) [2] - CRISPR Therapeutics has seen a 57.7% increase in share price year-to-date, significantly outperforming the industry average of 3.5% [2] Collaboration and Pipeline Expansion - In May 2025, CRISPR Therapeutics entered a collaboration with Sirius Therapeutics to develop and commercialize siRNA therapies, sharing costs and profits equally [4][5] - The collaboration allows CRISPR to exclusively license up to two siRNA programs and retain rights for clinical development and commercialization [5] - This partnership diversifies CRISPR's pipeline into RNA therapeutics, expanding beyond its traditional gene therapies [8] Potential of SRSD107 - If successful, SRSD107 could become a best-in-class therapy for patients at risk of life-threatening thromboembolic events due to co-morbid conditions [6] Casgevy Sales and Future Prospects - CRISPR's gene therapy, Casgevy, approved for sickle cell disease and transfusion-dependent beta-thalassemia, is gaining sales momentum, with $30.4 million recorded in Q2 2025 [9][10] - The company is advancing multiple next-generation gene-edited cell therapy programs, including CAR T candidates for various cancers and autoimmune diseases [10]