浙大研究团队发明“声控胶囊”控释药物

Core Insights - A research team from Zhejiang University has developed a bionic artificial cilia array inspired by cochlear hair cells, which visualizes sound signal analysis through acoustic resonance mechanisms and utilizes this principle to create a "sound-controlled capsule" for drug release [1][5] Group 1: Research Development - The research was published in the journal "Nature-Biomedical Engineering" on the 24th, with contributions from professors and researchers at Zhejiang University [1] - The team used 3D modeling and high-precision 3D printing technology to simulate the structure of cochlear hair cell cilia, designing and fabricating bionic artificial cilia arrays with varying length-to-diameter ratios [1] Group 2: Experimental Findings - Experiments showed that the artificial cilia arrays, with different diameters and length-to-diameter ratios, vibrate under sound wave stimulation, with resonance frequencies ranging from 100 to 6000 Hz, covering the common frequency range of human hearing [2] - The integration of cilia with different resonance frequencies in a single array demonstrated potential for visualizing sound frequency analysis and significantly accelerated liquid flow rates, enhancing the release and diffusion of model drugs in liquid environments [2] Group 3: Future Applications - The team constructed a capsule-type drug delivery device responsive to acoustic resonance, capable of selectively triggering the release of insulin or glucagon by applying different sound wave frequencies [5] - Future optimizations of the bionic artificial cilia array's material and structural design aim to broaden the frequency response range and improve the analysis of complex sound signals, potentially integrating with brain-machine interfaces and electronic drugs [5]