Core Insights - A breakthrough in regenerative medicine has been achieved by a research team from the University of Zurich, demonstrating the ability to reverse brain damage caused by stroke through stem cell transplantation, promoting neuron regeneration and significantly restoring motor function [1][2] Group 1: Research Findings - The study published in Nature Communications indicates that one in four adults will experience a stroke in their lifetime, with about half suffering from long-term sequelae such as paralysis or speech disorders due to irreversible brain cell death [1] - The research utilized human-induced pluripotent stem cell-derived neural stem cells, which can be reprogrammed from ordinary somatic cells and have the ability to differentiate into various neural system cells [1] - In the experiment, a permanent brain injury similar to that in humans was induced in genetically modified mice, which do not reject transplanted human cells [1] Group 2: Results of Stem Cell Transplantation - The transplanted stem cells successfully survived in the damaged brain area, with most differentiating into mature neurons that established functional connections with the host's existing neural network, indicating integration into the brain's operational system [2] - A broad regeneration effect was observed, including the formation of new blood vessels in the damaged area, a significant reduction in brain inflammation, and restoration of the blood-brain barrier integrity [2] - The collaboration with Kyoto University ensured that all stem cells were prepared without using animal-derived reagents, laying the groundwork for future safe applications in humans [2] Group 3: Clinical Implications - The research highlights a critical one-week window for transplantation post-stroke, suggesting that delayed intervention may yield better outcomes, providing a valuable preparation period for clinical treatment [2][3] - The study opens new clinical prospects by achieving biological repair of structural brain damage rather than merely alleviating symptoms, potentially offering a treatment paradigm for other neurodegenerative diseases such as Parkinson's or spinal cord injuries [3] - Future human trials could significantly alter the landscape of neuro-rehabilitation medicine if the efficacy of this approach is validated [3]
再生医学在脑修复领域迈出关键一步:干细胞移植逆转动物中风损伤
Ke Ji Ri Bao·2025-09-25 23:09