我科学家在老年痴呆疾病模型犬认知障碍分子机制解析上取得重要进展

Core Insights - A research team led by Huang Lusheng from Jiangxi Agricultural University has revealed a new mechanism mediating synaptic damage in cognitive impairment dogs, focusing on the interaction between microglial cells C1QA and neurons CRT [1][3] - The study published in the journal "National Science Review" highlights the increasing prevalence of Alzheimer's disease (AD), with over 55 million patients globally and approximately 9.83 million in China [1][3] Group 1 - The research innovatively uses dogs as a model to systematically explain the molecular mechanisms of aging and related cognitive impairments, enhancing the application of dogs as a translational model for human AD [3] - The team has provided a theoretical basis for early intervention in canine cognitive impairment by analyzing the differences in glial cells under physiological aging and pathological states of cognitive decline [3] - The findings may offer potential molecular biomarkers for the early diagnosis of dementia and provide important cellular mechanism references for understanding its pathogenesis [3]