我国科研团队在酶催化研究领域取得新突破

Core Insights - The research team discovered a metal isomerase with a new function in catalyzing hexose oxidative cleavage, revealing a sophisticated strategy for microbial metabolic balance through "one enzyme, dual function" [1][2] Group 1: Research Findings - The study elucidates a novel mechanism for carbohydrate oxidative cleavage, expanding the understanding of metal enzyme catalytic reactions [2] - The enzyme Art22, derived from the natural product "circular enediyne," exhibits a typical TIM barrel structure and can catalyze both hexose isomerization and oxidative cleavage [1] - Art22 performs isomerization and oxidative cleavage sequentially at the same active site, playing dual roles in synthesizing antibacterial molecules and deactivating toxic byproducts within the microbial cell [1]