我国科学家揭示猪蓝耳病细菌继发感染的关键机制

Core Viewpoint - The research conducted by the Animal Immunity and Metabolism Innovation Team at the Lanzhou Veterinary Research Institute of the Chinese Academy of Agricultural Sciences reveals the key mechanism by which pigs infected with the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) are prone to secondary bacterial infections, providing new strategies and drug targets for controlling this global issue in the pig farming industry [1] Summary by Relevant Sections - Research Findings - The study identifies that after pigs are infected with PRRSV, they often suffer from secondary bacterial infections, leading to a significant increase in mortality rates and substantial economic losses in the pig farming sector [1] - The research team discovered that PRRSV activates a specific protein in pig lung cells, which rearranges the cell's internal "skeleton" to form a unique "scaffold" structure, increasing the number of adhesion "receptors" on the cell surface, facilitating bacterial invasion [1] - Implications for the Industry - This research provides insights into the molecular mechanisms by which viruses assist bacterial invasion, offering new targets and strategies for the development of drugs, vaccines, or gene editing techniques for disease prevention in pigs [1]