US Stocks Mixed; Dow Falls 100 Points

Market Overview - U.S. stocks showed mixed performance with the Dow Jones index falling over 100 points, down 0.23% to 46,651.42, while NASDAQ rose 0.37% to 22,865.21 and S&P 500 gained 0.20% to 6,729.08 [1] - In commodities, oil increased by 0.7% to $61.28, gold rose 1.8% to $3,977.90, silver was up 1.1% to $48.485, and copper fell 1.4% to $5.0365 [6] Company Highlights - Advanced Micro Devices (AMD) shares surged over 27% following a significant agreement with OpenAI to deploy up to 6 gigawatts of AMD Instinct GPU power for AI infrastructure, with an initial rollout of 1 gigawatt of MI450 GPUs planned for the second half of 2026 [2][3] - Spruce Biosciences, Inc. saw its shares increase by 316% to $36.73 after receiving U.S. FDA breakthrough therapy designation for its enzyme replacement therapy for Sanfilippo Syndrome Type B [9] - OneMedNet Corporation's shares surged 143% to $2.4999 after selecting Palantir Technologies to enhance its healthcare AI and real-world data analytics operations [9] - Society Pass Incorporated's shares rose by 113% to $2.9987 [9] - Lixiang Education Holding Co., Ltd. experienced a drop of 58% to $1.19 [9] - Skye Bioscience, Inc. shares fell 54% to $2.18 after failing to meet primary endpoints in a study [9] - Dragonfly Energy Holdings Corp. shares decreased by 28% to $1.36 following a $25 million public offering priced at $1.25 per share [9] International Markets - European shares were mixed, with the eurozone's STOXX 600 gaining 0.1%, while Spain's IBEX 35 Index and London's FTSE 100 both fell by 0.1% [7] - Asian markets closed mixed, with Japan's Nikkei 225 gaining 4.75%, Hong Kong's Hang Seng index falling 0.67%, and India's BSE Sensex rising 0.72% [10]