AlphaTON Capital and Subsidiary Cyncado Therapeutics Pioneer Convergence of Digital Assets and Oncology Innovation: Exploring Tokenization Framework for Mesothelioma Program as it Advances Toward Q1 2026 First Patient Dosing

Core Insights - AlphaTON Capital Corp is at the forefront of the decentralized science (DeSci) movement, leveraging its TON infrastructure to enhance cancer research, particularly in mesothelioma through a non-binding letter of intent for tokenization of single-indication economics for TT-4 [1][2][4] Company Overview - AlphaTON is the only Nasdaq-listed company that operates a strategic TON token treasury while advancing first-in-class immunotherapy assets, integrating decentralized science principles with medical research funding [2][3] - The company aims to democratize access to cancer research and align global stakeholders with patient outcomes through innovative financing mechanisms [4][8] Clinical Development - Cyncado Therapeutics, a wholly owned subsidiary of AlphaTON, is preparing for the clinical start-up of TT-4, an oral A2B receptor antagonist, with first-patient dosing expected in Q1 2026 [5][14] - The initial study will focus on safety dose-escalation in solid tumor patients, followed by a larger mesothelioma-focused study at major U.S. cancer centers [5] Scientific Validation - Preclinical data for TT-4 shows promising results, including 90% tumor growth inhibition in murine models when combined with anti-PD-1 therapy and 60% complete responses [7][6] - The drug's mechanism aims to neutralize immune suppression and enhance anti-tumor responses, demonstrating superior activity compared to existing checkpoint inhibitors [7] Decentralized Science Movement - The DeSci movement seeks to transform how scientific research is funded and shared, with AlphaTON's tokenization initiative positioning it as a leader in this space [8][9] - The company aims to enhance transparency in clinical development and create direct value alignment between research supporters and therapeutic success [13] Strategic Vision - AlphaTON's business model integrates its validator operations, ecosystem investments, and therapeutic programs to create synergies that accelerate the path from laboratory to patient [9][10] - The exploratory LOI for tokenization is designed to preserve traditional therapeutic development pathways while exploring innovative funding models [10]