科学家用人类干细胞构建出“类血细胞” 成功模拟胎儿血液发育过程

Core Insights - Researchers at Cambridge University have developed "blood-like cells" using human stem cells, which can simulate multiple key stages of early human development, including the generation of blood stem cells [1][2] - The new human embryo-like model accurately replicates the initiation of the hematopoietic system in embryos, providing a powerful tool for drug screening, early blood and immune system development research, and modeling blood diseases [2] Group 1 - The embryo-like structures exhibit self-organization capabilities, forming the three primary germ layers (ectoderm, mesoderm, and endoderm) by day two of cultivation [1] - By day eight, beating heart cells were observed, which in real embryos will eventually develop into the heart [1] - On day thirteen, the team noted distinct red blood spots, confirming the generation of functional blood cells [1] Group 2 - The ability to produce human blood cells in the laboratory marks a significant step in regenerative medicine, allowing for the potential creation of blood cells that are genetically matched to patients, thus avoiding immune rejection [2] - The model captures the "second wave" of hematopoiesis during human development, which can produce adaptive lymphocytes, including T cells, opening new avenues for studying blood development in both healthy and cancerous states [2]