Gilead to Spotlight New Virology Data Across HIV, Viral Hepatitis and Respiratory Diseases at IDWeek 2025

Core Insights - Gilead Sciences is set to present new antiviral research data at IDWeek 2025, focusing on HIV, viral hepatitis, and respiratory diseases, highlighting its leadership in antiviral science and commitment to innovative solutions for affected communities [1][2]. HIV Prevention Research - New data from the Phase 3 PURPOSE trials reinforce the safety profile of Yeztugo (lenacapavir) as a twice-yearly pre-exposure prophylaxis (PrEP) option, showing no significant drug-drug interactions with commonly used hormonal contraceptives and gender-affirming hormone therapy [3][4]. - The PURPOSE 2 trial indicates that Yeztugo is a viable PrEP option for gender-diverse populations and those affected by substance use, emphasizing its inclusivity [4]. HIV Treatment Research - Gilead's data at IDWeek emphasizes the strong clinical profile of Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) as a preferred treatment for HIV, with patients reporting higher satisfaction after switching from intramuscular cabotegravir + rilpivirine to Biktarvy [5][6]. - A 12-week interim analysis of the Phase 4 EMPOWER study shows that individuals switching to Biktarvy maintained viral suppression without serious adverse events and reported increased treatment satisfaction [6]. Respiratory Viruses / COVID-19 Research - Gilead will present findings on the effectiveness of Veklury (remdesivir) in high-risk COVID-19 populations, including those with renal impairment and solid organ transplant recipients, reinforcing its role as a standard of care [9][17]. - New analyses indicate that Veklury retains antiviral activity against recent SARS-CoV-2 variants, with significant data on treatment patterns among immunocompromised individuals [18][19]. Overview of Scientific Presentations - Gilead's presentations will cover a wide range of topics, including adherence and safety of HIV prevention methods, treatment satisfaction among HIV patients, and the effectiveness of antiviral treatments for respiratory viruses [7][10].