我国胰岛素口服递送取得新突破 有望破解世界级难题

Core Insights - A research team from Beihang University, in collaboration with other institutions, has developed an oral insulin formulation with "smart navigation" capabilities, offering new hope for diabetes patients to avoid daily injections [1][2] - The study highlights the challenges of oral insulin delivery, including degradation by gastric acid and enzymes, absorption barriers in the intestinal epithelium, and rapid metabolism by the liver [1] - The innovative delivery system, inspired by milk exosomes, combines natural stability with intelligent responsiveness, potentially revolutionizing oral drug delivery for large molecules [1][2] Summary by Sections - Research Development - The new oral insulin formulation, termed MiNVs, has achieved a bioavailability of 20.4%, over 20 times that of traditional oral formulations, meeting clinical application standards [2] - In diabetic pig models, MiNVs effectively reduced blood sugar levels to normal within 2 to 4 hours, maintaining control for over 8 hours while keeping body weight stable [2] - Safety and Efficacy - Safety tests on healthy pigs showed no abnormalities in vital organs after 14 days of high-dose MiNVs administration, indicating good biocompatibility [2] - The intelligent delivery system employs a "three-level navigation" mechanism for precise insulin delivery, setting a new benchmark for the development of oral large molecule drugs [2] - Future Potential - The technology has significant clinical translation potential, promising to improve treatment adherence and quality of life for diabetes patients while providing new avenues for oral delivery of other biopharmaceuticals [2]