新型磁刺激治疗方案有助改善精神分裂症症状

Core Insights - A new method to effectively improve negative symptoms of schizophrenia has been discovered by Dr. Han Yuyi from Harbin First Specialized Hospital, with results published in the international journal "Brain Stimulation" [1][2] Group 1: Research Findings - Schizophrenia patients experience both positive symptoms (hallucinations, delusions) and negative symptoms (emotional flatness, social withdrawal), with the latter often overlooked [1] - Current drug treatments are effective for positive symptoms but show limited efficacy for negative symptoms [1] - Non-invasive neurostimulation techniques, such as transcranial magnetic stimulation, are being explored for treating negative symptoms, but existing methods have significant limitations [1] Group 2: Clinical Study - The study involved 80 schizophrenia patients primarily exhibiting negative symptoms, divided into a true stimulation group and a sham stimulation group [2] - The true stimulation group received individualized accelerated intermittent theta-burst stimulation for 10 days, with four sessions daily, each consisting of 1800 pulses [1][2] - Results showed a significant reduction in negative symptoms in the true stimulation group after four weeks, with a response rate of 77.5% compared to 17.5% in the sham group [2] Group 3: Effectiveness and Future Plans - The average score for negative symptoms in the true stimulation group decreased by 4.10 points, with an effect size of 0.83, indicating moderate to high treatment effectiveness [2] - Neuroactivity changes in the left middle temporal gyrus and weakened functional connectivity between the midbrain and middle temporal gyrus were associated with symptom improvement [2] - Future plans include larger multi-center clinical studies to optimize treatment parameters for broader patient access [2]