Arcutis to Present New Quality of Life and Long-Term Data with ZORYVE® (roflumilast) Cream 0.15% and 0.05% for the Treatment of Atopic Dermatitis at the Fall Clinical Dermatology Conference

Core Insights - Arcutis Biotherapeutics announced new data on ZORYVE® (roflumilast) cream, showing improvements in quality of life for atopic dermatitis patients, particularly in reducing sleep disruptions and providing long-term disease control for individuals aged 2 years and older [1][2][5] Clinical Data - ZORYVE cream demonstrated significant improvements in sleep and itch reduction in patients aged 2 to 5 years and 6 years and older, based on patient-reported outcomes from three Phase 3 trials [3][6] - The treatment was well-tolerated, with adverse events reported in ≤6% of patients, and serious adverse events in <1% [6][12] Long-term Efficacy - Long-term data from the INTEGUMENT-OLE trial indicated that ZORYVE cream maintained or improved disease control over 56 weeks, with a notable percentage of patients achieving 'Clear' or 'Almost Clear' status [8][12] - The median duration of disease control for patients switching to twice-weekly treatment was 238 days for children aged 2-5 and 281 days for older patients [12] Product Recognition - ZORYVE has received multiple awards, including the "2025 Best of Beauty Breakthrough Award" from Allure and the National Psoriasis Foundation's Seal of Recognition, highlighting its clinical impact and industry recognition [10] Indications and Usage - ZORYVE cream is indicated for the topical treatment of mild to moderate atopic dermatitis in pediatric patients aged 2 to 5 years and in patients aged 6 years and older [11][13]