Aprea Therapeutics Provides Clinical Update from ACESOT-1051 Trial Showing Early Signals of Activity for WEE1 Kinase Inhibitor APR-1051

Core Insights - Aprea Therapeutics, Inc. has provided an update on the Phase 1 ACESOT-1051 study, showing promising results for its WEE1 inhibitor, APR-1051, in patients with advanced solid tumors [1][2][5] Study Results - At the 100 mg dose level of APR-1051, 3 out of 4 patients achieved stable disease according to RECIST v1.1 criteria [1][5][6] - Disease stabilization was observed in patients with tumors harboring mutations relevant to WEE1 kinase inhibition, specifically FBXW7, CCNE1, KRAS, and TP53 [5][6][11] - The trial is currently progressing to a higher dose level of 150 mg following successful results from the 100 mg cohort [5][6] Presentation and Data - Preliminary results from the ACESOT-1051 trial will be presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics [2][5] - The poster presentation will summarize updated data with a cutoff date of September 17, 2025 [2] Company Overview - Aprea Therapeutics focuses on developing innovative cancer therapies that target specific vulnerabilities in cancer cells while minimizing damage to healthy cells [7] - The company's clinical programs include APR-1051, an oral small-molecule inhibitor of WEE1 kinase, and ATRN-119, a macrocyclic small molecule ATR inhibitor [7]